Clinical Studies

Nutrition Intervention with Oral Nutritional Supplements (ONS)

ONS have been demonstrated to be more effective than dietary advice and snacks; greater intakes of energy, protein, and micronutrients and significantly fewer complications have been shown in patients taking ONS.

Read Full Article >

* Readmission defined as return to a study hospital for any diagnosis. Data measured delayed readmission and do not include patients not readmitted due to recovery or death.

Abstracts and Clinical Summary: Decreased Readmissions, LOS and Episode Cost

This study outlines the effect oral nutrition supplements have on hospital readmission, detail the impact of oral nutrition supplementation of patients with COPD, and show how oral nutritional supplements provided during hospitalization were associated with decreased length of stay and episode costs.

Read Full Article >

Clinical Summary: Decreased Readmission

Gariballa and colleagues published a study in 2006 in older hospital patients with acute disease showing that over a 6-month time period, 29% of patients in the ONS group were readmitted to the hospital vs. 40% of patients in the control group. This represents a 28% reduction in hospital readmissions.

Read Clinical Summary (PDF 80 KB)

Clinical Summary: Decreased Readmission and Reduced Complications

In 2012 Cawood et al published a meta-analysis with the conclusion that high-protein ONS is associated with significant reduction in complications, fewer readmissions to the hospital, and improvement in handgrip strength.

Read Clinical Summary (PDF 79 KB)

Disease-Related Malnutrition Clinical Summary Overview

Both disease-related malnutrition and sarcopenia are associated with substantial adverse outcomes affecting both the patient and the healthcare system, including increased morbidity, mortality, rehospitalization rates, and healthcare costs. Clinicians are urged to screen, assess, and treat these conditions so as to adequately address the full spectrum of patients’ nutritional issues.

Read Full Article >

References

1. Lacson E, Jr., Wang W, Zebrowski B, Wingard R, Hakim RM. Am J Kidney Dis. Oct 2012;60(4):591-600.
2. Caglar K, Fedje L, Dimmitt R, Hakim RM, Shyr Y, Ikizler TA. Kidney Int. Sep 2002;62(3):1054-1059.

Condition Driven: Kidney Disease

Patients with chronic kidney disease have specialized needs – and they look to you and your health care colleagues for nutritional support that is specialized, too.

Proper nutrition for people on dialysis >

References

1. Moreland SS. Nutrition screening and counseling in adults with lung cancer: a systematic review of the evidence. Clinical journal of oncology nursing. Oct 2010;14(5):609-614.
2. Di Sebastiano KM, Mourtzakis M. A critical evaluation of body composition modalities used to assess adipose and skeletal muscle tissue in cancer. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. Oct 2012;37(5):811-821.
3. Nayel H, el-Ghoneimy E, el-Haddad S. Impact of nutritional supplementation on treatment delay and morbidity in patients with head and neck tumors treated with irradiation. Nutrition. Jan-Feb 1992;8(1):13-18.
4. Davidson W, Teleni L, Muller J, et al. Malnutrition and chemotherapy-induced nausea and vomiting: implications for practice. Oncology nursing forum. Jul 2012;39(4):E340-345.
5. Bosaeus I, Daneryd P, Lundholm K. Dietary intake, resting energy expenditure, weight loss and survival in cancer patients. The Journal of nutrition. Nov 2002;132(11 Suppl):3465S-3466S.
6. Chang PH, Yeh KY, Huang JS, et al. Pretreatment performance status and nutrition are associated with early mortality of locally advanced head and neck cancer patients undergoing concurrent chemoradiation. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies. May 2013;270(6):1909-1915.
7. Odelli C, Burgess D, Bateman L, et al. Nutrition support improves patient outcomes, treatment tolerance and admission characteristics in oesophageal cancer. Clinical oncology. Dec 2005;17(8):639-645.
8. Dewys WD, Begg C, Lavin PT, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. The American journal of medicine. Oct 1980;69(4):491-497.
9. Laviano A, Meguid MM. Nutritional issues in cancer management. Nutrition. May 1996;12(5):358-371.
10. Andreyev HJ, Norman AR, Oates J, Cunningham D. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? European journal of cancer. Mar 1998;34(4):503-509.
11. Pressoir M, Desne S, Berchery D, et al. Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres.British journal of cancer. Mar 16 2010;102(6):966-971.
12. Ottery FD. Cancer cachexia: prevention, early diagnosis, and management. Cancer practice. Mar-Apr 1994;2(2):123-131.
13. American College of Surgeons Commission on Cancer. Cancer Program Standards 2012: Ensuring Patient Centered Care. Chicago IACoS.
14. Oncology Nutrition For Clinical Practice. 2013.

Condition Driven: Oncology

Abbott Nutrition has developed therapeutic nutrition products that can help in the nutritional management of your patients before, during, and after their cancer treatment.

Fight malnutrition in cancer patients >

References

1. Centers for Disease Control and Prevention. Diabetes Report Card 2012. Atlanta, GA: Centers for Disease Control and Prevention, US Department of Health and Human Services; 2012.
2. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: U.S. Department of Health and Human Services; 2014.

Condition Driven: Diabetes

You and your patients can depend on products and programs from Abbott Nutrition – developed using the latest scientific information – to help support diabetes management through healthy eating and lifestyle modifications.

Nutrition and diabetes >

References

1. Hegazi RA, Wischmeyer PE. Crit Care. 2011;15:234
2. McClave SA, Martindale RG, Vanek VW, et al. JPEN J Parenter Enteral Nutr. May-Jun 2009;33(3):277-316.
3. Critical Care Nutrition. 2015 Canadian Clinical Practice Guidelines http://www.criticalcarenutrition.com/index.php?option=com_content&view=category&layout=blog&id=25&Itemid=109. Accessed June 18, 2015.
4. Pontes-Arruda A, Martins LF, de Lima SM, et al. Crit Care. 2011;15(3):R144.
5. Bedi NM, McGurk S, Burgess AM, Rawn JD. JPEN J Parenter Enteral Nutr. 2011;35(1):138.

Critical Care

Abbott Nutrition can assist you in providing the appropriate formula to meet your patients’ specific nutritional needs. An algorithm published in 2011 can provide guidance on how, when, and what to feed your patients based on clinical conditions.¹ Other Critical Care Guidelines ^2,3 may also be helpful in guiding you in selecting the appropriate product that will meet your patients' individual needs.

View HCP Resources >

References

1. Itoh M, Tsuji T, Nemoto K, Nakamura H, Aoshiba K. Nutrients. Apr 2013;5(4):1316-35.
2. GOLD. Global Strategy for the Diagnosis, Management, and Prevention of COPD. 2014 http://www.goldcopd.com/uploads/users/files/GOLD_Report_2014_Oct30.pdf
3. Stratton RJ, Green CJ, Elia M. Disease-related malnutrition: an evidence based approach to treatment. Oxford, United Kingdom: CABI Publishing (CABI International), 2003.
4. Cochrane WJ, et al. J Hum Nutr Diet. 2004;17:3-11.
5. Battaglia S, Spatafora M, Paglino G, et al. Eur Respir J. 2011;37:1340-5.
6. Hsu M-F, Ho S-C, Kuo H-P, et al. COPD. 2014;11:325-32.
7. Engelen MPKJ, Schols AMWJ, Baken WC, et al. Eur Respir J. 1994;7:1793-7.
8. Schols AM, Soeters PB, Dingemans AM, et al. Am Rev Respir Dis. 1993;147:1151–56.
9. Vermeeren MA, Creutzberg EC, Schols AM, et al. Respir Med. 2006;100:1349–55
10. Collins PF, Stratton RJ, Elia M. Am J Clin Nutr. 2012;95:1385-95.
11. Ferreira IM, Brooks D, White J, Goldstein R. Cochrane Database Syst Rev. 2012, Issue 12. Art. No.: CD000998. DOI: 10.1002/14651858.CD000998.pub3.
12. Collins PF, Elia M, Stratton RJ. Respirol J. 2013;18:616-29.
13. Alish CJ, et al. Diabetes Tech & Ther. 2010;12:419-425.http://www.ncbi.nlm.nih.gov/pubmed/20470226

Condition Driven: Pulmonary Disease

Abbott Nutrition knows that recovery from illness and improving the strength of your patients are important. People with pulmonary disease, such as COPD, are at an increased risk for disease-related malnutrition and loss of lean body mass.¹

Preventing Malnutrition in patients with COPD >

*Readmission defined as return to a study hospital for any diagnosis. Data measured delayed readmission and do not include patients not readmitted due to recovery or death.

References

¹ Coats KG et al. J Am Diet Assoc 1993; 93: 27-33.

² Giner M et al. Nutrition 1996; 12: 23-29.

³ Thomas DR et al. Am J Clin Nutr 2002; 75: 308-313.

⁴ Norman K et al. Clin Nutr. 2008; 27: 5-15.

Malnutrition

As a worldwide leader in nutrition science, research, and development, Abbott Nutrition is committed to increasing the awareness of the critical role nutrition plays in improving patient outcomes.

Advance Patient Nutrition >

Preterm Nutrition

Effect of Carotenoid Supplementation on Plasma Carotenoids, Inflammation and Visual Development in Preterm Infants LP Rubin, GM Chan, BM Barrett-Reis, AB Fulton, RM Hansen, TL Ashmeade, JS Oliver, AD Mackey, RA Dimmit, EE Hartmann, DH Adamkin Journal of Perinatology 2012;32(6):418-424. Study funded by Abbott Nutrition.

Read Summary (PDF 707 KB)

Human Milk Fortification: Past, Present and Future

Highlights from Dr. Jae Kim's presentation at Hot Topics in Neonatology Conference, 2013

Effect of an Extensively Hydrolyzed Protein Milk Fortifier on the Growth of Preterm Infants

Download the abstract or find the full publication in the Journal of Pediatric Gastroenterology and Nutrition. Kim JH, et al. Growth and tolerance of preterm infants fed a new extensively hydrolyzed liquid human milk fortifier. JPGN. 2015;61:665-671.

Read Abstract (PDF 368 KB)

* At significant levels

2’-FL HUMAN MILK OLIGOSACCHARIDE (HMO)

Similar to those who are breastfed, infants fed a formula containing 2’-fucosyllactose have lower inflammatory cytokines in a randomized controlled trial...

Read Article >

Learn More About HMOs >

Learn More About Similac® with 2'-FL HMO >

Footnotes

*Markers of stem-cell differentiation into neural progenitor cells as measured in cell culture.

†Provided in OptiGRO formulas as RRR-alpha-tocopheryl acetate

‡RRR alpha-tocopherol.

§Primary cortical neurons from neonatal rats.

OptiGRO: Benefits beyond DHA alone

OptiGRO is our exclusive blend of DHA, Lutein and Vitamin E; these important ingredients are found in breast milk.

Lutein

• Lutein supports eye health. Lutein concentrates in the macula of the eye¹. The macula is involved in relaying information to the visual cortex of the brain^2,3.
• Lutein is the predominant carotenoid in the infant brain and is found in four areas of the brain related to learning and development⁴.
• Watch a brief video about lutein here

Vitamin E

• All Vitamin E is not the same. Similac exclusively uses a form of naturally occurring Vitamin E^*5.
• The form of natural Vitamin E exclusively used in Similac is the most biologically available form^†6.
• Natural Vitamin E is the predominant form found in mother’s milk⁷.
• Natural vitamin E is the predominant form found in the infant’s brain⁵.

DHA

• DHA is an ingredient that supports brain development^8-10
  • Like breast milk, OptiGRO has DHA to support brain development⁸.
  • DHA is highly susceptible to damage from oxidation^10,11.

Recent Studies

Boff JC, Jensen SK, Johnson EJ, Kuchan MJ. RRR-alpha-tocopherol is the predominant vitamin E stereoisomer in human infant brain. Poster presented at: Advances and Controversies in Clinical Nutrition; December 5-7, 2013; Washington, DC.

Moulton C, Kuchan M, Lai C-S, Jensen SK, Innis S. RRR-α-tocopherol is the predominant vitamin E stereoisomer in human breast milk. Poster presented at: 2nd International Congress on Nutrition and Growth; January 20-February 1, 2014; Barcelona, Spain.

Vazhappilly R, Lai C-S, Kuchan M. Natural vitamin E and lutein protects DHA from peroxidation in neurons. Poster presented at: American College of Nutrition 54th Annual Conference; November 13-16, 2013; San Diego, CA.

Footnotes

*Provided in OptiGRO formulas as RRR-alpha-tocopheryl acetate

†RRR alpha-tocopherol.

References

1. Hegazi RA, Wischmeyer PE. Crit Care. 2011;15:234.
2. McClave SA, Martindale RG, Vanek VW, et al. JPEN J Parenter Enteral Nutr. May-Jun 2009;33(3):277-316.
3. Critical Care Nutrition. 2015 Canadian Clinical Practice Guidelines http://www.criticalcarenutrition.com/index.php?option=com_content&view=category&layout=blog&id=25&Itemid=109. Accessed June 18, 2015.
4. Pontes-Arruda A, Martins LF, de Lima SM, et al. Crit Care. 2011;15(3):R144.
5. Bedi NM, McGurk S, Burgess AM, Rawn JD. JPEN J Parenter Enteral Nutr. 2011;35(1):138.
6. Itoh M, Tsuji T, Nemoto K, Nakamura H, Aoshiba K. Nutrients. Apr 2013;5(4):1316-35.
7. Moulton C, et al. Natural vitamin E (RRR-alpha-tocopherol) is the predominant vitamin E stereoisomer in human milk. Poster presented at: 2nd International Conference on Nutrition and Growth; January 20-February 1, 2014; Barcelona, Spain.
8. Auestad N, et al. Pediatrics. 2001;108:372-381.
9. Brenna JT, et al. Am J Clin Nutr. 2007;85(6):1457-1464.
10. Vazhappilly R, et al. Effect of lutein and alpha-tocopherol on DHA peroxidation in primary cortical neurons. Poster presented at: American College of Nutrition 54th Annual Conference; November 13-16, 2013; San Diego, CA.
11. Wardlaw GM, et al. Perspectives in Nutrition. 6th ed. New York, NY: McGraw Hill; 2004.

Caloric Density of Formulas

Is the macronutrient intake of formula-fed infants greater than breastfed infants in early infancy? Shelly N. Hester, Deborah S. Hustead, Amy D.Mackey, Atul Singhal, and Barbara J. Marriage Journal of Nutrition and Metabolism 2012;891201 Study funded by Abbott Nutrition.

Read Article (PDF 519 KB)

Term Nutrition

Plasma Carotenoid Concentrations of Infants Are Increased by Feeding a Milk-Based Infant Formula Supplemented With Carotenoids Amy D. Mackey, Daniel Albrecht, Jeffery Oliver, Timberly Williams, Amy C. Long, Pamela T. Price Journal of the Science of Food and Agriculture 2013;93(8):1945-1952. Study funded by Abbott Nutrition

Read Summary (PDF 707 KB)

Infant Nutrition

Effect of Dietary Ribonucleotides on Infant Immune Status. Part 2: Immune Cell Development Rachael H. Buck, Debra L. Thomas, Timothy R. Winship, Christopher T. Cordle, Matthew J. Kuchan, Geraldine E. Baggs, Joseph P. Schaller, J. Gary Wheeler Pediatric Research 2004;56(6):891-900. Study funded by Abbott Nutrition

Read Summary (PDF 701 KB)