Similac Pro-Advance® Step 2

SIMILAC PRO-ADVANCE^® STEP 2

with 2'-FL oligosaccharide / DHA- and ARA-fortified

Transition formula for infants who are 6 months or older. For oral or tube feeding use.

Download Product Guide (PDF 119 KB)

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

6818113

Similac Pro-Advance® Step 2; 584 g can; 6/case

6818313

Similac Pro-Advance® Step 2; 859 g can; 6/case

Features

Specially formulated to help bridge the nutritional gaps that can be associated with the transition to table foods.
Calcium enriched (50% more calcium than Similac Pro-Advance® Step 1) to support growing infants.
Our most advanced formula with 2’-FL.^*
2'-FL^* is structurally identical to 2'-FL human milk oligosaccharide (HMO),¹ the most abundant HMO found in the breast milk of most mothers.²
Addition of 2'-FL^* to infant formula may help support the development and regulation of the formula-fed baby's immune response to be closer to that of breastfed infants.^3,†
DHA, the most abundant Omega-3 fatty acid in brain and eyes.⁴
Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes.^5,6,7 Recent studies show that lutein may have a role in visual and cognitive development.⁸
Vitamin E, a dietary antioxidant that protects fats in body tissues from oxidation.⁹ Similac Pro-Advance® uses natural vitamin E,^‡ the most abundant form found in breast milk and in the infant brain.^10,11
Non-GMO.^§
Easy to digest.^¶
Gluten-free.
Kosher.
Halal.

PRECAUTIONS

Not for parenteral use.

^* Not derived from human milk.

¹ Weichert S et al. Nutr Res 2013;33(10):831-8.

^† Breast milk is best for babies, contains many immune factors not available in infant formula, and its use is recommended for as long as possible during infancy.

² Castanys-Muñoz E et al. Nutr Rev 2013;71(12):773-89.

^‡ RRR-alpha-tocopherol, the most bioactive form of vitamin E.

³ Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.

^§ Ingredients not genetically engineered.

⁴ Calder PC. Ann Nutr Metab 2016;69(Suppl. 1):8-21.

^¶ Similar to other infant formulas.

⁵ Zimmer JP, et al. Clin Ophtalmol. 2007;1:25-35.

⁶ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

⁷ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

⁸ Johnson EJ. Nutr Rev. 2014;72(9):605-12.

⁹ Canadian Food Inspection Agency: Health Claims – Nutrient Function Claims. Last modiﬁed on 2019-10-31. [Accessed online on 2023-11-14]

¹⁰ Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Preparation and Use:

Your baby’s health depends on carefully following these directions. Proper hygiene, preparation, mixing, and storage are important when using infant formula. Failure to follow these directions could result in severe harm. Use as directed by your health care professional.

Preparation instructions

Wash hands thoroughly with soap and water.
Sterilize equipment: Place washed bottles, nipples, rings, caps, and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes. Sterilize water: In another pot, boil water at a rolling boil for 2 minutes. Cool to room temperature prior to mixing.
Prepare formula using enclosed scoop - see Mixing Guide. Return dry scoop to container.
Cap bottle; shake well; attach nipple.

Once feeding begins, use within 1 hour or discard.

Mixing Guide

Cooled sterlized water	Unpacked Level Scoop(s)
60 mL	1
120 mL	2
180 mL	3
240 mL	4

Once mixed, refrigerate bottles immediately; use within 24 hours. Once feeding begins, use within 1 hour or discard.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Powder

Similac Pro-Advance® Step 2; 584 g can; 6/case
Similac Pro-Advance® Step 2; 859 g can; 6/case

Serving size: 100 g (Powder)

Value

Product Characteristics

AT STANDARD DILUTION

Caloric Density (Cal/mL)
0.68

Protein (% of total energy)
8.2

Protein Source
Dry or evaporated skim milk, whey protein concentrate, whey protein hydrolysate

Fat (% of total energy)
48.8

Omega-6:Omega-3 Ratio
9.7:1

MCT oil (% of total fats)
0

Fat Source
High oleic safflower oil, soy oil, coconut oil, M. alpina oil, Schizochytrium sp. oil, soy lecithin

Carbohydrate (% of total energy)
43.0

Carbohydrate Source
Lactose, fructooligosaccharides, 2’-fucosyllactose

Total Cal:g Nitrogen Ratio
309:1

Nonprotein Cal:g Nitrogen Ratio
284:1

Water (g/L)
904

Osmolality (mOsm/kg water)
303

Renal Solute Load (mOsm/L)
97

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
516 (2160)

Protein, g
11

Taurine, mg
35

Carnitine, mg
7.6

Tryptophan, mg
183

Fat, g
29

Linoleic Acid, g
4

Linolenic Acid, g
0.38

Arachidonic Acid (ARA), g
0.11

Docosahexaenoic Acid (DHA), g
0.055

Carbohydrate, g
56

Fibre, g
1.4

2'-fucosyllactose (2'-FL), mg
153

Nucleotides, mg
55

Vitamins

Inositol, mg
30

Lutein, mg
0.058

Vitamin A, IU
1454

Vitamin D, IU
309

Vitamin E, IU
21

Vitamin K, mg
0.069

Vitamin C, mg
77

Thiamine, mg
0.61

Riboflavin, mg
0.81

Niacin, mg
5.5

Vitamin B6, mg
0.31

Folic Acid, mg
0.053

Vitamin B12, mg
0.0013

Pantothenic Acid, mg
2.3

Biotin, mg
0.019

Choline, mg
77

Minerals

Sodium, mg
137

Potassium, mg
609

Chloride, mg
338

Calcium, mg
609

Phosphorus, mg
304

Magnesium, mg
40

Iron, mg
9.2

Zinc, mg
3.9

Iodine, mg
0.1

Copper, mg
0.41

Manganese, mg
0.037

Selenium, mg
0.01

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Powder

Similac Pro-Advance® Step 2; 584 g can; 6/case
Similac Pro-Advance® Step 2; 859 g can; 6/case

Lactose, Dry or Evaporated Skim Milk, High Oleic Safflower Oil, Whey Protein Concentrate, Soy Oil, Coconut Oil, Fructooligosaccharides, Whey Protein Hydrolysate, M. Alpina Oil (A Source Of ARA), 2'-Fucosyllactose (2'-FL), Schizochytrium Sp. Oil (A Source of DHA), Soy Lecithin, L-Tryptophan, Taurine, M-Inositol, Cytidine 5'-Monophosphate, Ascorbyl Palmitate, Disodium Guanosine 5'-Monophosphate, Disodium Uridine 5'-Monophosphate, Adenosine 5'-Monophosphate, Mixed Tocopherols, L-Carnitine, Lutein, MINERALS (Tricalcium Phosphate, Calcium Carbonate, Potassium Citrate, Potassium Hydroxide, Magnesium Chloride, Sodium Chloride, Ferrous Sulphate, Zinc Sulphate, Copper Sulphate, Manganese Sulphate, Potassium Iodide, Sodium Selenite), VITAMINS (Ascorbic Acid, Choline Bitartrate, D-Alpha-Tocopheryl Acetate, Niacinamide, Calcium D-Pantothenate, Vitamin A Palmitate, Thiamine Chloride Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Beta-Carotene, Phylloquinone, Vitamin D3, D-Biotin, and Cyanocobalamin).

Contains: Milk, Soy.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

6818113

Similac Pro-Advance® Step 2; 584 g can; 6/case

6818313

Similac Pro-Advance® Step 2; 859 g can; 6/case

Features

Specially formulated to help bridge the nutritional gaps that can be associated with the transition to table foods.
Calcium enriched (50% more calcium than Similac Pro-Advance® Step 1) to support growing infants.
Our most advanced formula with 2’-FL.^*
2'-FL^* is structurally identical to 2'-FL human milk oligosaccharide (HMO),¹ the most abundant HMO found in the breast milk of most mothers.²
Addition of 2'-FL^* to infant formula may help support the development and regulation of the formula-fed baby's immune response to be closer to that of breastfed infants.^3,†
DHA, the most abundant Omega-3 fatty acid in brain and eyes.⁴
Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes.^5,6,7 Recent studies show that lutein may have a role in visual and cognitive development.⁸
Vitamin E, a dietary antioxidant that protects fats in body tissues from oxidation.⁹ Similac Pro-Advance® uses natural vitamin E,^‡ the most abundant form found in breast milk and in the infant brain.^10,11
Non-GMO.^§
Easy to digest.^¶
Gluten-free.
Kosher.
Halal.

PRECAUTIONS

Not for parenteral use.

^* Not derived from human milk.

¹ Weichert S et al. Nutr Res 2013;33(10):831-8.

^† Breast milk is best for babies, contains many immune factors not available in infant formula, and its use is recommended for as long as possible during infancy.

² Castanys-Muñoz E et al. Nutr Rev 2013;71(12):773-89.

^‡ RRR-alpha-tocopherol, the most bioactive form of vitamin E.

³ Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.

^§ Ingredients not genetically engineered.

⁴ Calder PC. Ann Nutr Metab 2016;69(Suppl. 1):8-21.

^¶ Similar to other infant formulas.

⁵ Zimmer JP, et al. Clin Ophtalmol. 2007;1:25-35.

⁶ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

⁷ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

⁸ Johnson EJ. Nutr Rev. 2014;72(9):605-12.

⁹ Canadian Food Inspection Agency: Health Claims – Nutrient Function Claims. Last modiﬁed on 2019-10-31. [Accessed online on 2023-11-14]

¹⁰ Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Preparation and Use:

Preparation instructions

Wash hands thoroughly with soap and water.
Sterilize equipment: Place washed bottles, nipples, rings, caps, and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes. Sterilize water: In another pot, boil water at a rolling boil for 2 minutes. Cool to room temperature prior to mixing.
Prepare formula using enclosed scoop - see Mixing Guide. Return dry scoop to container.
Cap bottle; shake well; attach nipple.

Once feeding begins, use within 1 hour or discard.

Mixing Guide

Cooled sterlized water	Unpacked Level Scoop(s)
60 mL	1
120 mL	2
180 mL	3
240 mL	4

Once mixed, refrigerate bottles immediately; use within 24 hours. Once feeding begins, use within 1 hour or discard.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Powder

Similac Pro-Advance® Step 2; 584 g can; 6/case
Similac Pro-Advance® Step 2; 859 g can; 6/case

Serving size: 100 mL (at standard dilution)

Value

Product Characteristics

AT STANDARD DILUTION

Caloric Density (Cal/mL)
0.68

Protein (% of total energy)
8.2

Protein Source
Dry or evaporated skim milk, whey protein concentrate, whey protein hydrolysate

Fat (% of total energy)
48.8

Omega-6:Omega-3 Ratio
9.7:1

MCT oil (% of total fats)
0

Fat Source
High oleic safflower oil, soy oil, coconut oil, M. alpina oil, Schizochytrium sp. oil, soy lecithin

Carbohydrate (% of total energy)
43.0

Carbohydrate Source
Lactose, fructooligosaccharides, 2’-fucosyllactose

Total Cal:g Nitrogen Ratio
309:1

Nonprotein Cal:g Nitrogen Ratio
284:1

Water (g/L)
904

Osmolality (mOsm/kg water)
303

Renal Solute Load (mOsm/L)
97

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
68 (280)

Protein, g
1.4

Taurine, mg
4.5

Carnitine, mg
0.99

Tryptophan, mg
24

Fat, g
3.7

Linoleic Acid, g
0.53

Linolenic Acid, g
0.05

Arachidonic Acid (ARA), g
0.014

Docosahexaenoic Acid (DHA), g
0.0072

Carbohydrate, g
7.3

Fibre, g
0.18

2'-fucosyllactose (2'-FL), mg
20

Nucleotides, mg
7.2

Vitamins

Inositol, mg
4

Lutein, mg
0.0076

Vitamin A, IU
190

Vitamin D, IU
40

Vitamin E, IU
2.7

Vitamin K, mg
0.009

Vitamin C, mg
10

Thiamine, mg
0.08

Riboflavin, mg
0.11

Niacin, mg
0.72

Vitamin B6, mg
0.041

Folic Acid, mg
0.0069

Vitamin B12, mg
0.00017

Pantothenic Acid, mg
0.3

Biotin, mg
0.0025

Choline, mg
10

Minerals

Sodium, mg
18

Potassium, mg
80

Chloride, mg
44

Calcium, mg
80

Phosphorus, mg
40

Magnesium, mg
5.2

Iron, mg
1.2

Zinc, mg
0.5

Iodine, mg
0.013

Copper, mg
0.053

Manganese, mg
0.0048

Selenium, mg
0.0013

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Powder

Similac Pro-Advance® Step 2; 584 g can; 6/case
Similac Pro-Advance® Step 2; 859 g can; 6/case

Contains: Milk, Soy.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Availability

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

LIST NUMBER

ITEM

6818113

Similac Pro-Advance® Step 2; 584 g can; 6/case

6818313

Similac Pro-Advance® Step 2; 859 g can; 6/case

Features

Specially formulated to help bridge the nutritional gaps that can be associated with the transition to table foods.
Calcium enriched (50% more calcium than Similac Pro-Advance® Step 1) to support growing infants.
Our most advanced formula with 2’-FL.^*
2'-FL^* is structurally identical to 2'-FL human milk oligosaccharide (HMO),¹ the most abundant HMO found in the breast milk of most mothers.²
Addition of 2'-FL^* to infant formula may help support the development and regulation of the formula-fed baby's immune response to be closer to that of breastfed infants.^3,†
DHA, the most abundant Omega-3 fatty acid in brain and eyes.⁴
Lutein, an antioxidant found in breast milk and concentrated in the infant brain and eyes.^5,6,7 Recent studies show that lutein may have a role in visual and cognitive development.⁸
Vitamin E, a dietary antioxidant that protects fats in body tissues from oxidation.⁹ Similac Pro-Advance® uses natural vitamin E,^‡ the most abundant form found in breast milk and in the infant brain.^10,11
Non-GMO.^§
Easy to digest.^¶
Gluten-free.
Kosher.
Halal.

PRECAUTIONS

Not for parenteral use.

^* Not derived from human milk.

¹ Weichert S et al. Nutr Res 2013;33(10):831-8.

^† Breast milk is best for babies, contains many immune factors not available in infant formula, and its use is recommended for as long as possible during infancy.

² Castanys-Muñoz E et al. Nutr Rev 2013;71(12):773-89.

^‡ RRR-alpha-tocopherol, the most bioactive form of vitamin E.

³ Goehring KC, et al. J Nutr. 2016;146(12):2559-2566.

^§ Ingredients not genetically engineered.

⁴ Calder PC. Ann Nutr Metab 2016;69(Suppl. 1):8-21.

^¶ Similar to other infant formulas.

⁵ Zimmer JP, et al. Clin Ophtalmol. 2007;1:25-35.

⁶ Krinsky NI, et al. Annu Rev Nutr. 2003;23:171-201.

⁷ Vishwanathan R, et al. JPGN. 2014;59(5):659-65.

⁸ Johnson EJ. Nutr Rev. 2014;72(9):605-12.

⁹ Canadian Food Inspection Agency: Health Claims – Nutrient Function Claims. Last modiﬁed on 2019-10-31. [Accessed online on 2023-11-14]

¹⁰ Kuchan MJ, et al. Curr Dev Nutr. 2018;2:nzy055

¹¹ Kuchan MJ, et al. Br J Nutr. 2016;116(1):126-31.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Preparation

Directions for Preparation and Use:

Preparation instructions

Wash hands thoroughly with soap and water.
Sterilize equipment: Place washed bottles, nipples, rings, caps, and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes. Sterilize water: In another pot, boil water at a rolling boil for 2 minutes. Cool to room temperature prior to mixing.
Prepare formula using enclosed scoop - see Mixing Guide. Return dry scoop to container.
Cap bottle; shake well; attach nipple.

Once feeding begins, use within 1 hour or discard.

Mixing Guide

Cooled sterlized water	Unpacked Level Scoop(s)
60 mL	1
120 mL	2
180 mL	3
240 mL	4

Once mixed, refrigerate bottles immediately; use within 24 hours. Once feeding begins, use within 1 hour or discard.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Nutrition

Unflavored Powder

Similac Pro-Advance® Step 2; 584 g can; 6/case
Similac Pro-Advance® Step 2; 859 g can; 6/case

Serving size: 100 Cal

Value

Product Characteristics

AT STANDARD DILUTION

Caloric Density (Cal/mL)
0.68

Protein (% of total energy)
8.2

Protein Source
Dry or evaporated skim milk, whey protein concentrate, whey protein hydrolysate

Fat (% of total energy)
48.8

Omega-6:Omega-3 Ratio
9.7:1

MCT oil (% of total fats)
0

Fat Source
High oleic safflower oil, soy oil, coconut oil, M. alpina oil, Schizochytrium sp. oil, soy lecithin

Carbohydrate (% of total energy)
43.0

Carbohydrate Source
Lactose, fructooligosaccharides, 2’-fucosyllactose

Total Cal:g Nitrogen Ratio
309:1

Nonprotein Cal:g Nitrogen Ratio
284:1

Water (g/L)
904

Osmolality (mOsm/kg water)
303

Renal Solute Load (mOsm/L)
97

Recommended Tube Size for Gravity/Pump Feeding (Fr)
N/A

Amount per Serving

Nutrient Data

ENERGY, Cal (kJ)
100 (418)

Protein, g
2.1

Taurine, mg
6.7

Carnitine, mg
1.5

Tryptophan, mg
35

Fat, g
5.5

Linoleic Acid, g
0.78

Linolenic Acid, g
0.075

Arachidonic Acid (ARA), g
0.021

Docosahexaenoic Acid (DHA), g
0.011

Carbohydrate, g
10.8

Fibre, g
0.27

2'-fucosyllactose (2'-FL), mg
30

Nucleotides, mg
10.7

Vitamins

Inositol, mg
5.9

Lutein, mg
0.011

Vitamin A, IU
282

Vitamin D, IU
60

Vitamin E, IU
4

Vitamin K, mg
0.0134

Vitamin C, mg
15

Thiamine, mg
0.12

Riboflavin, mg
0.16

Niacin, mg
1.06

Vitamin B6, mg
0.06

Folic Acid, mg
0.01

Vitamin B12, mg
0.00026

Pantothenic Acid, mg
0.5

Biotin, mg
0.0037

Choline, mg
15

Minerals

Sodium, mg
27

Potassium, mg
118

Chloride, mg
65

Calcium, mg
118

Phosphorus, mg
59

Magnesium, mg
7.7

Iron, mg
1.8

Zinc, mg
0.75

Iodine, mg
0.02

Copper, mg
0.079

Manganese, mg
0.0071

Selenium, mg
0.002

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

Ingredients

Unflavored Powder

Similac Pro-Advance® Step 2; 584 g can; 6/case
Similac Pro-Advance® Step 2; 859 g can; 6/case

Contains: Milk, Soy.

Values listed are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.